Prediction and Classification of Allergenicity within Protein Families
نویسندگان
چکیده
منابع مشابه
Statistical evaluation of local alignment features for prediction of protein allergenicity using supervised classification algorithms
In this work a statistical evaluation of alignment based features for prediction of protein allergenicity was performed. The evaluation consisted of four key components: 1) A new high quality in-house database consisting of 318 allergenic and 1007 non-allergenic amino acid sequences. 2) Three different supervised classification algorithms. 3) A large set of local alignments procedures using a w...
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آب حاصل از بارش منبع تأمین نیازهای بی شمار جانداران به ویژه انسان است و هرگونه کاهش در کم و کیف آن مستقیماً حیات موجودات زنده را تحت تأثیر منفی قرار می دهد. نوسان سال به سال بارش از ویژگی های اساسی و بسیار مهم بارش های سالانه ایران محسوب می شود که آثار زیان بار آن در تمام عرصه های اقتصادی، اجتماعی و حتی سیاسی- امنیتی به نحوی منعکس می شود. چون میزان آب ناشی از بارش یکی از مولفه های اصلی برنامه ...
15 صفحه اولGenomic classification of protein-coding gene families.
This chapter reviews analytical tools currently in use for protein classification, and gives an overview of the C. elegans proteome. Computational analysis of proteins relies heavily on hidden Markov models of protein families. Proteins can also be classified by predicted secondary or tertiary structures, hydrophobic profiles, compositional biases, or size ranges. Strictly orthologous protein f...
متن کاملAllergenFP: allergenicity prediction by descriptor fingerprints
MOTIVATION Allergenicity, like antigenicity and immunogenicity, is a property encoded linearly and non-linearly, and therefore the alignment-based approaches are not able to identify this property unambiguously. A novel alignment-free descriptor-based fingerprint approach is presented here and applied to identify allergens and non-allergens. The approach was implemented into a four step algorit...
متن کاملPlant protein families as a basis for predicting the allergenicity of food proteins
Plant proteins can be classified into families and superfamilies based on their sequence relationships. Comparison of these families with accepted lists of plant food-protein allergens demonstrates that only a small number of families contain characterized allergens with most of those that sensitize via the gastrointestinal tract falling into only two large superfamilies. These observations are...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2015.12.1004